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This text explores one of the most profound yet vexing issues in law: how to accommodate advances in the medical and scientific understanding of causation within the province of law. It provides a framework for analysis of different theories of medical, scientific and legal causation, as well as modes or tests relating to the proof of causation offered in different forensic and medical contexts.;Notions of risk in determining causation in criminal and civil law, the nature of proof in medicine and the law, issues of morality, responsibility and justice in the context of legal causation, as well as aspects of causation pertaining specifically to forensic medicine and coronial law are analyzed from an interdisciplinary perspective.